Which intermediate is produced after the conversion of isocitrate in the Citric Acid Cycle?

After isocitrate undergoes enzymatic transformation in the Citric Acid Cycle, it is converted into alpha-ketoglutarate. This reaction is catalyzed by the enzyme isocitrate dehydrogenase, which facilitates the oxidative decarboxylation of isocitrate. During this process, isocitrate loses one carbon atom as carbon dioxide and is oxidized, resulting in the reduction of NAD+ to NADH. The formation of alpha-ketoglutarate is a key step in the cycle, contributing to the production of additional energy carriers, such as NADH, which are critical for the subsequent reactions that generate ATP. Thus, the conversion from isocitrate to alpha-ketoglutarate is crucial for the overall functioning of the Citric Acid Cycle.