Is the conversion of succinyl CoA to succinate by succinyl CoA synthetase reversible?

The conversion of succinyl CoA to succinate by succinyl CoA synthetase is indeed classified as a reversible reaction in the context of metabolism. In the citric acid cycle, this step involves the conversion of succinyl CoA into succinate, accompanied by the production of ATP or GTP, depending on the organism and tissue type.

The reversibility of this reaction stems from the fact that succinyl CoA can undergo hydrolysis, resulting in the generation of succinate and CoA. The direction of the reaction can shift based on cell conditions, such as concentration of substrates and products, as well as the availability of ATP or GTP. In metabolic pathways, especially those involving the citric acid cycle, many reactions are not strictly unidirectional and can be influenced by the cellular environment.

In summary, the export of succinate from succinyl CoA can proceed in both directions, indicating that the reaction is indeed reversible, thus validating the answer provided.